For almost all of the 19th century, medicines were not highly powerful, main Oliver Wendell Holmes Sr. to famously remark in 1842 that "if all medicines on earth had been thrown into the sea, It will be all the higher for mankind and all of the worse to the fishes".[27]: https://trentonvdkr41741.scrappingwiki.com/952344/arzneimittel_die_s%C3%A4ulen_moderner_medizin_und_gesundheit