In the LSD-certain crystal framework, the side chain with the lid residue L209EL2 sorts intensive hydrophobic contacts with each LSD and surrounding residues in TMs III, IV, and V (Figure 4C). Once the lid moved aside to expose the binding pocket in simulation, quite a few of those contacts broke. https://rylanqenqn.dreamyblogs.com/35451698/detailed-notes-on-limited-edition-exclusive-lsd-crystal