There exists a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to reduce afferent pain transmission and deliver analgesia. For that reason, drugs like clonidine that focus on alpha-two receptors can influence the transmission of discomfort. Relates to clonidine: oral https://jamesb036mkh7.wikifordummies.com/user