There is a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to minimize afferent ache transmission and make analgesia. For that reason, drugs like clonidine that goal alpha-2 receptors can affect the transmission of ache. Clonidine is a long-phrase medication. https://bookmarkingace.com/story19801614/the-ultimate-guide-to-onolidine