There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to decrease afferent ache transmission and deliver analgesia. Hence, medicine like clonidine that target alpha-2 receptors can affect the transmission of suffering. Combining these coronary heart drugs with clonidine https://fredv380csk9.wikitidings.com/user