New selective PAD4 inhibitors binding a calcium-deficient kind of the PAD4 enzyme have validated the critical enzymatic function of human and mouse PAD4 in the two histone citrullination and neutrophil extracellular trap development for, to our knowledge, The 1st time. The therapeutic probable of PAD4 inhibitors can now be explored. https://genghisv000hsc2.webbuzzfeed.com/profile